1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

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Chemical Name:1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate
CAS No.:1258976-16-7
Molecular Formula:C₂₃H₂₈ClN₅O₃S
Molecular Weight:490.026
Hs Code.:

1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Synonyms:1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

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Chemical Property of 1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

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Technology Process of 1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

There total 6 articles about 1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 157327-43-0
tert-butyl 5-acetyl-4-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate

: 1258976-15-6
2-(3-chloro-4-isopropoxyphenyl)-5-hydrazinyl-1,3,4-thiadiazole

: 1258976-16-7
1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:: In ISOPROPYLAMIDE; at 150 ℃; for 1h; Product distribution / selectivity; Irradiation with microwave;

Reference yield:

: 1258440-64-0
2-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazole

: 1258976-16-7
1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / isopropyl alcohol / 16 h / 105 °C / Inert atmosphere

2: acetic acid / ethanol / Microwave irradiation

With hydrazine hydrate; acetic acid; In ethanol; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1258976-16-7
1,1-dimethylethyl 2-(5-{3-chloro-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16.5 h / 20 °C

2: trichlorophosphate / 19 h / 20 - 90 °C

3: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 °C

4: hydrazine hydrate / isopropyl alcohol / 16 h / 105 °C / Inert atmosphere

5: acetic acid / ethanol / Microwave irradiation

With tert.-butylnitrite; oxalyl dichloride; hydrazine hydrate; acetic acid; N,N-dimethyl-formamide; copper(ll) bromide; trichlorophosphate; In ethanol; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512