24469-05-4Relevant articles and documents
Easily accessible auxiliary for palladium-catalyzed intramolecular amination of C(sp2)-H and C(sp3)-H bonds at δ- And ε-Positions
Wang, Chao,Chen, Changpeng,Zhang, Jingyu,Han, Jian,Wang, Qian,Guo, Kun,Liu, Pei,Guan, Mingyu,Yao, Yingming,Zhao, Yingsheng
supporting information, p. 9884 - 9888,5 (2014/10/15)
An easily synthesized and accessible N,O-bidentate auxiliary has been developed for selective C-H activation under palladium catalysis. The novel auxiliary showed its first powerful application in C-H functionalization of remote positions. Both C(sp2)-H and C(sp3)-H bonds at δ- and ε-positions were effectively activated, thus giving tetrahydroquinolines, benzomorpholines, pyrrolidines, and indolines in moderate to excellent yields by palladium-catalyzed intramolecular C-H amination.
Synthesis of aromatic α-aminoesters: Palladium-catalyzed long-range arylation of primary Csp3-H bonds
Aspin, Sam,Goutierre, Anne-Sophie,Larini, Paolo,Jazzar, Rodolphe,Baudoin, Olivier
supporting information, p. 10808 - 10811 (2013/01/15)
Remote control: The title reaction for β-Iζ arylation of α-amino esters with aryl bromides is described. This reaction, which occurs selectively at the terminal position of linear alkyl chains, gives rise to synthetically useful (hetero)arylalanines and homologues after debenzylation (see scheme). Copyright
INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE
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Page/Page column 120-121, (2008/06/13)
The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these comp
INHIBITORS OF TRYPTASE
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Page/Page column 201, (2008/06/13)
The present invention related to certain inhibitors of tryptase that are inhibitors of tryptase, pharmaceutical composition comprising these compounds and method of treating asthma, allergic rhinitis, and/or Chronic Obstructive Pulmonary Disease utilizing these compounds.
An Expedient and Practical Method for the Synthesis of A Diverse Series of Cyclopropane α-Amino Acids and Amines
Wurz, Ryan P.,Charette, Andre B.
, p. 1262 - 1269 (2007/10/03)
A practical synthesis for the preparation of a diverse series of cyclopropane α-amino acids is described. Nitrocyclopropane carboxylates can be readily prepared through treatment of α-nitroesters and iodobenzene diacetate or α-nitro-α-diazoesters with a R
Enantioselective enzyme catalysed ammoniolysis of amino acid derivatives. Effect of temperature
Lopez-Serrano, Paloma,Wegman, Margreth A.,Van Rantwijk, Fred,Sheldon, Roger A.
, p. 235 - 240 (2007/10/03)
The lipases from Candida antarctica (B type), Thermomyces lanuginosus and Pseudomonas alcaligenes catalysed the enantioselective ammoniolysis of free amino acid esters. In the ammoniolysis of phenylalanine methyl ester catalysed by T. lanuginosus lipase a