1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one

Base Information

• Chemical Name: 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one
• CAS No.: 1428318-76-6
• Molecular Formula: C₁₉H₁₈N₄O
• Molecular Weight: 318.378
• Mol file: 1428318-76-6.mol

Synonyms:1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one

Chemical Property of 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one

There total 6 articles about 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzyl azide (622-79-7) + N-(2-phenylethynyl)pyrrolidin-2-one (683246-77-7) → 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one (1428318-76-6)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; In dichloromethane; at 20 ℃; for 12h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.7b03123

Reference yield: 78.0%

2-pyrrolidinon (616-45-5) + 1-benzyl-5-fluoro-4-phenyl-1H-1,2,3-triazole (1428318-58-4) → 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one (1428318-76-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 70 ℃; for 3h;

DOI:10.1002/anie.201204979

Reference yield:

phenylacetylene (536-74-3) → 1-(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)pyrrolidin-2-one (1428318-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide / tetrahydrofuran / 3 h

2: potassium fluoride / acetonitrile; water / 0.17 h / 180 °C / Microwave irradiation

3: sodium hydride / tetrahydrofuran; mineral oil / 3 h / 70 °C

With potassium fluoride; copper(l) iodide; sodium hydride; In tetrahydrofuran; water; acetonitrile; mineral oil;

DOI:10.1002/anie.201204979

upstream raw materials:

2-pyrrolidinon

1-benzyl-5-fluoro-4-phenyl-1H-1,2,3-triazole

1-benzyl-4-phenyl-5-iodo-1,2,3-triazole

phenylacetylene