3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

Base Information

Chemical Name:3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate
CAS No.:1256240-59-1
Molecular Formula:C₂₁H₂₄ClN₃O₅
Molecular Weight:433.892
Hs Code.:

Synonyms:3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

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Chemical Property of 3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

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Technology Process of 3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

There total 5 articles about 3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256241-04-9
3-ethoxycarbonyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

: 74-89-5
methylamine

: 1256240-59-1
3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

Guidance literature:: In methanol; ethanol; at 60 ℃; for 3h; sealed tube;

Reference yield:

: 240401-28-9
2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1256240-59-1
3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene / 14 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 20 °C

2.2: pH 10

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.33 h / 0 - 20 °C

3.2: 15 h / 60 °C

4.1: ethanol; methanol / 3 h / 60 °C / sealed tube

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1256241-03-8
2-(4-chlorophenoxy)-7-aza-spiro[3.5]-nonane

: 1256240-59-1
3-methylcarbamoyl-isoxazol-5-ylmethyl 2-(4-chlorophenoxy)-7-aza-spiro[3.5]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.33 h / 0 - 20 °C

1.2: 15 h / 60 °C

2.1: ethanol; methanol / 3 h / 60 °C / sealed tube

With N-ethyl-N,N-diisopropylamine; In methanol; ethanol; 1,2-dichloro-ethane;