cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

Base Information

Chemical Name:cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate
CAS No.:1207108-99-3
Molecular Formula:C₅₀H₆₇NO₃S
Molecular Weight:762.153
Hs Code.:

Synonyms:cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

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Technology Process of cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

There total 2 articles about cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1207108-98-2
cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

: 1207108-99-3
cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1248/cpb.59.1386

Reference yield:

: 57-88-5
cholesterol

: 177582-21-7
fmoc-S-4-methoxytrityl-L-cysteine

: 1207108-99-3
cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C

2: piperidine / dichloromethane / 0.33 h / 20 °C

With piperidine; dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1248/cpb.59.1386

Reference yield:

: 1207108-99-3
cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

: 1373121-76-6
cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 20 °C

3: acetic acid / tetrahydrofuran; water / 2.5 h / 60 °C

With triethylsilane; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1248/cpb.59.1386