cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

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Chemical Name:cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate
CAS No.:1373121-76-6
Molecular Formula:C₅₄H₇₅N₃O₇S₂
Molecular Weight:942.337
Hs Code.:

Synonyms:cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

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Chemical Property of cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

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Technology Process of cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

There total 5 articles about cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1207109-01-0
cholest-5-en-3-yl (13R)-13-amino-1-(2-naphthyl)-6-oxo-2-(4-{[(tetrahydro-2H-pyran-2-yloxy)amino]carbonyl}benzyl)-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

: 1373121-76-6
cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 60 ℃; for 2.5h;
DOI:10.1248/cpb.59.1386

Reference yield:

: 1207108-98-2
cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

: 1373121-76-6
cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / dichloromethane / 0.33 h / 20 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

3: dimethyl sulfoxide / 2 h / 20 °C

4: acetic acid / tetrahydrofuran; water / 2.5 h / 60 °C

With piperidine; triethylsilane; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1248/cpb.59.1386

Reference yield:

: 1207108-99-3
cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

: 1373121-76-6
cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylsilane; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

2: dimethyl sulfoxide / 2 h / 20 °C

3: acetic acid / tetrahydrofuran; water / 2.5 h / 60 °C

With triethylsilane; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1248/cpb.59.1386