cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

Base Information

Chemical Name:cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate
CAS No.:1207108-98-2
Molecular Formula:C₆₅H₇₇NO₅S
Molecular Weight:984.396
Hs Code.:

Synonyms:cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

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Chemical Property of cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

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Technology Process of cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

There total 1 articles about cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.9%

: 57-88-5
cholesterol

: 177582-21-7
fmoc-S-4-methoxytrityl-L-cysteine

: 1207108-98-2
cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1248/cpb.59.1386

Reference yield: 39.0%

: 1207108-98-2
cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

: 1207108-99-3
cholest-5-en-3-yl (2R)-2-amino-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 0.333333h;
DOI:10.1248/cpb.59.1386

Reference yield:

: 1207108-98-2
cholest-5-en-3-yl (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-{[(4-methoxyphenyl)(diphenyl)methyl]sulfanyl}propanoate

: 1373121-76-6
cholest-5-en-3-yl (13R)-13-amino-2-{4-[(hydroxyamino)carbonyl]benzyl}-1-(2-naphthyl)-6-oxo-5,7-dioxa-10,11-dithia-2-azatetradecan-14-oate

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / dichloromethane / 0.33 h / 20 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

3: dimethyl sulfoxide / 2 h / 20 °C

4: acetic acid / tetrahydrofuran; water / 2.5 h / 60 °C

With piperidine; triethylsilane; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1248/cpb.59.1386