2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

Base Information

Chemical Name:2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile
CAS No.:1354339-96-0
Molecular Formula:C₂₂H₂₀ClN₅O₂
Molecular Weight:421.886
Hs Code.:

Synonyms:2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

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Chemical Property of 2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

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Technology Process of 2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

There total 5 articles about 2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1354340-05-8
4-((1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)propylamino)-2-chloro-3-propylbenzonitrile

: 1354339-96-0
2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

Guidance literature:: With ammonium fluoride; In methanol; for 65h; Reflux;

Reference yield:

: 1354340-03-6
N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

: 1354339-96-0
2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; triphenylphosphine; iodine / dichloromethane; tetrahydrofuran / -15 - 20 °C / Inert atmosphere

2: ammonium fluoride / methanol / 65 h / Reflux

With ammonium fluoride; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1354340-01-4
(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

: 1354339-96-0
2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -30 °C / Inert atmosphere

1.2: 120 h / -30 - 20 °C

2.1: 1H-imidazole / tetrahydrofuran / 48 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: triethylamine; triphenylphosphine; iodine / dichloromethane; tetrahydrofuran / -15 - 20 °C / Inert atmosphere

4.1: ammonium fluoride / methanol / 65 h / Reflux

With 1H-imidazole; ammonium fluoride; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;