(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

Base Information

Chemical Name:(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid
CAS No.:1354340-01-4
Molecular Formula:C₁₄H₁₇ClN₂O₃
Molecular Weight:296.754
Hs Code.:

Synonyms:(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

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Chemical Property of (2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

Chemical Property:

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Technology Process of (2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

There total 1 articles about (2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 924626-89-1
2-chloro-4-fluoro-3-propylbenzonitrile

: 632-20-2,134357-96-3,7013-32-3,82822-12-6
D-Threonine

: 1354340-01-4
(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

Guidance literature:: 2-chloro-4-fluoro-3-propylbenzonitrile; D-Threonine; In dimethyl sulfoxide; at 20 ℃;

With potassium carbonate; In dimethyl sulfoxide; at 20 - 80 ℃; for 40h;

With citric acid; In water;

Reference yield: 73.0%

: 43038-36-4
4-cyanobenzohydrazide

: 1354340-01-4
(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

: 1354340-02-5
N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

Guidance literature:: 4-cyanobenzohydrazide; (2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid; In tetrahydrofuran; at -30 ℃; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -30 - 20 ℃; for 120h;

Reference yield:

: 1354340-01-4
(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

: 1354339-96-0
2-Chloro-4-((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropylamino)-3-propylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -30 °C / Inert atmosphere

1.2: 120 h / -30 - 20 °C

2.1: 1H-imidazole / tetrahydrofuran / 48 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: triethylamine; triphenylphosphine; iodine / dichloromethane; tetrahydrofuran / -15 - 20 °C / Inert atmosphere

4.1: ammonium fluoride / methanol / 65 h / Reflux

With 1H-imidazole; ammonium fluoride; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;