N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

Base Information

Chemical Name:N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide
CAS No.:1354340-03-6
Molecular Formula:C₂₈H₃₆ClN₅O₃Si
Molecular Weight:554.164
Hs Code.:

Synonyms:N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

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Chemical Property of N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

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Technology Process of N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

There total 3 articles about N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1354340-02-5
N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1354340-03-6
N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

Guidance literature:: N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide; tert-butyldimethylsilyl chloride; With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 48h;

With water; In tetrahydrofuran; n-heptane; at 20 ℃; for 0.5h;

Reference yield:

: 1354340-01-4
(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

: 1354340-03-6
N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -30 °C / Inert atmosphere

1.2: 120 h / -30 - 20 °C

2.1: 1H-imidazole / tetrahydrofuran / 48 h / 20 °C

2.2: 0.5 h / 20 °C

With 1H-imidazole; In tetrahydrofuran;

Reference yield:

: 924626-89-1
2-chloro-4-fluoro-3-propylbenzonitrile

: 1354340-03-6
N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 20 °C

1.2: 40 h / 20 - 80 °C

2.1: tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 120 h / -30 - 20 °C

3.1: 1H-imidazole / tetrahydrofuran / 48 h / 20 °C

3.2: 0.5 h / 20 °C

With 1H-imidazole; In tetrahydrofuran; dimethyl sulfoxide;