N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

Base Information

Chemical Name:N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide
CAS No.:1354340-02-5
Molecular Formula:C₂₂H₂₂ClN₅O₃
Molecular Weight:439.901
Hs Code.:

Synonyms:N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

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Chemical Property of N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

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Technology Process of N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

There total 2 articles about N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 43038-36-4
4-cyanobenzohydrazide

: 1354340-01-4
(2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid

: 1354340-02-5
N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

Guidance literature:: 4-cyanobenzohydrazide; (2R,3S)-2-(3-Chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoic acid; In tetrahydrofuran; at -30 ℃; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -30 - 20 ℃; for 120h;

Reference yield:

: 924626-89-1
2-chloro-4-fluoro-3-propylbenzonitrile

: 1354340-02-5
N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 20 °C

1.2: 40 h / 20 - 80 °C

2.1: tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 120 h / -30 - 20 °C

In tetrahydrofuran; dimethyl sulfoxide;

Reference yield: 84.0%

: 1354340-02-5
N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1354340-03-6
N'-((2R,3S)-3-(tert-Butyldimethylsilyloxy)-2-(3-chloro-4-cyano-2-propylphenylamino)butanoyl)-4-cyanobenzohydrazide

Guidance literature:: N'-((2R,3S)-2-(3-chloro-4-cyano-2-propylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide; tert-butyldimethylsilyl chloride; With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 48h;

With water; In tetrahydrofuran; n-heptane; at 20 ℃; for 0.5h;