Technology Process of 8-benzyl 3-ethyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate
There total 10 articles about 8-benzyl 3-ethyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-2,4-dioxo-1,8-diazaspiro[4.5]decane-3,8-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate;
With
sodium ethanolate;
In
2-methyltetrahydrofuran; ethanol;
at 15 - 25 ℃;
for 4h;
With
hydrogenchloride; citric acid;
In
2-methyltetrahydrofuran; ethanol; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid / zinc / 3 h / 60 °C
2.1: Chiralpak AD / methanol
3.1: lithium hexamethyldisilazane / tetrahydrofuran / -70 - -20 °C
3.2: 12 h / -5 - 5 °C
4.1: tetrabutyl ammonium fluoride; acetic acid / 2-methyltetrahydrofuran / 0.5 h / 20 °C
5.1: 0 °C
5.2: 12 h / -5 - 20 °C
6.1: -5 - 5 °C
6.2: -5 °C
7.1: sodium ethanolate / ethanol; 2-methyltetrahydrofuran / 4 h / 15 - 25 °C
With
tetrabutyl ammonium fluoride; sodium ethanolate; acetic acid; lithium hexamethyldisilazane;
zinc;
In
tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / tetrahydrofuran / 1 h / -50 - -10 °C
1.2: 3 h / -78 - 20 °C
2.1: acetic acid / zinc / 3 h / 60 °C
3.1: Chiralpak AD / methanol
4.1: lithium hexamethyldisilazane / tetrahydrofuran / -70 - -20 °C
4.2: 12 h / -5 - 5 °C
5.1: tetrabutyl ammonium fluoride; acetic acid / 2-methyltetrahydrofuran / 0.5 h / 20 °C
6.1: 0 °C
6.2: 12 h / -5 - 20 °C
7.1: -5 - 5 °C
7.2: -5 °C
8.1: sodium ethanolate / ethanol; 2-methyltetrahydrofuran / 4 h / 15 - 25 °C
With
tetrabutyl ammonium fluoride; sodium ethanolate; acetic acid; triethylamine; lithium hexamethyldisilazane;
zinc;
In
tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol;
![1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate](/Databaselist/images/loading.webp)
