2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

Base Information

Chemical Name:2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid
CAS No.:333458-92-7
Molecular Formula:C₂₀H₁₆Cl₂N₄O₃
Molecular Weight:431.278
Hs Code.:

Synonyms:2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

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Chemical Property of 2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

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Technology Process of 2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

There total 5 articles about 2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5866-98-8
2,6-dichloro-3-nitrobenzonitrile

: 333458-92-7
2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 83 percent / ethyl acetate; H₂O / 4.5 h / 10 - 20 °C

2.1: Cs₂CO₃ / dimethylformamide

3.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

4.1: tetrahydrofuran / 5 h / 20 °C

4.2: HgO / tetrahydrofuran

5.1: aq. H₂SO₄; AcOH / 2.5 h / 100 °C

With sulfuric acid; hydrogen; caesium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l

Reference yield:

: 333458-39-2
6-chloro-2-methylamino-3-nitrobenzonitrile

: 333458-92-7
2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Cs₂CO₃ / dimethylformamide

2.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

3.1: tetrahydrofuran / 5 h / 20 °C

3.2: HgO / tetrahydrofuran

4.1: aq. H₂SO₄; AcOH / 2.5 h / 100 °C

With sulfuric acid; hydrogen; caesium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l

Reference yield:

: 500735-14-8
2-acetyl-2-(2-cyano-3-methylamino-4-nitrophenyl)succinic acid dimethyl ester

: 333458-92-7
2-(2,6-dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydroimidazo[4,5-h]isoquinolin-6-ylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

2.1: tetrahydrofuran / 5 h / 20 °C

2.2: HgO / tetrahydrofuran

3.1: aq. H₂SO₄; AcOH / 2.5 h / 100 °C

With sulfuric acid; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm020446l