(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

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Chemical Name:(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate
CAS No.:1088697-38-4
Molecular Formula:C₄₃H₄₉NO₄S₂Si
Molecular Weight:736.084
Hs Code.:

Synonyms:(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

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Chemical Property of (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

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Technology Process of (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

There total 1 articles about (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 913288-73-0
(1S,2R)-2-(N-benzyl-N-mesitylenesulfonylamino)-1-phenylpropane-1-thiol

: 76271-74-4
2-((t-butyldiphenylsilyl)oxy)acetic acid

: 1088697-38-4
(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jo801720v

Reference yield: 89.0%

: 78-85-3,25120-30-3
2-methylpropenal

: 1088697-38-4
(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

: (1'S,2R,2'R,3R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-3-hydroxy-4-methyl-thiopent-4-enoate

: 1088697-62-4
(1'S,2S,2'R,3S)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-3-hydroxy-4-methyl-thiopent-4-enoate

Guidance literature:: (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

2-methylpropenal; In hexane; dichloromethane; at -78 - 0 ℃; for 4h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo801720v

Reference yield: 87.0%

: 1088697-38-4
(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate

: 590-86-3
isovaleraldehyde

: 1088697-57-7
(1'S,2S,2'R,3S)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-3-hydroxy-5-methyl-thiohexanoate

Guidance literature:: (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-(tert-butyl(diphenyl)silyloxy)-thioacetate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

isovaleraldehyde; In hexane; dichloromethane; at -78 - 0 ℃; for 4h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo801720v