2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide

Base Information

• Chemical Name: 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide
• CAS No.: 158751-78-1
• Molecular Formula: C₁₇H₁₉ClN₂O₅S
• Molecular Weight: 398.867
• Mol file: 158751-78-1.mol

Synonyms:2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide

Chemical Property of 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide

There total 5 articles about 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[2-(5-chloro-2-methoxy-benzoylamino)-ethyl]-2-methoxy-benzenesulfonyl chloride → 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide (158751-78-1)

Guidance literature:

With ammonium hydroxide; In acetone; at 20 ℃; for 1h;

DOI:10.1021/jm000985v

Reference yield:

4-Methoxyphenethylamine (55-81-2) → 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide (158751-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / pyridine / 1 h / 20 °C

2: ClSO₃H / 3 h / 20 °C

3: aq. NH₃ / acetone / 1 h / 20 °C

With pyridine; chlorosulfonic acid; ammonium hydroxide; In acetone;

DOI:10.1021/jm000985v

Reference yield:

2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-methoxyphenyl)-ethyl]-benzamide (158751-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / pyridine / 1 h / 20 °C

2: ClSO₃H / 3 h / 20 °C

3: aq. NH₃ / acetone / 1 h / 20 °C

With pyridine; chlorosulfonic acid; ammonium hydroxide; In acetone;

DOI:10.1021/jm000985v

upstream raw materials:

4-Methoxyphenethylamine

2-methoxy-5-chlorobenzoyl chloride

5-chloro-2-methoxy-N-(2-(4-methoxyphenyl)ethyl)benzamide

Downstream raw materials:

1-(5-(2-(5-chloro-2-methoxybenzamido)-ethyl)-2-methoxy-phenylsulfonyl)-3-methylthiourea

C₂₄H₃₀ClN₃O₅S₂

2-methoxy-5-chloro-N-{5-[1-sulfonylamino-N-(methylaminocarbonyl)-2-methoxyphenyl]-ethyl}-benzamide

C₂₀H₂₄ClN₃O₅S₂