(S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Base Information

Chemical Name:(S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone
CAS No.:157487-57-5
Molecular Formula:C₂₈H₃₅N₇O₇
Molecular Weight:581.629
Hs Code.:

Synonyms:(S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Suppliers and Price of (S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

There total 12 articles about (S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 149835-85-8
[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

: 157487-56-4
(S)-7-(4-Amino-butyl)-2-methyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

: 157487-57-5
(S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; acetic acid; for 2h; Ambient temperature;

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 157487-57-5
(S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Guidance literature:: Multi-step reaction with 12 steps

1: 32.6 g / AcCl / Heating

2: NBS, benzoyl-peroxide / CCl₄ / Heating

3: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

4: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

5: SOCl₂, DMF / 2 h / Ambient temperature

6: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

7: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

8: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

9: 99.5 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

10: 100 percent / 2.9N HCl / acetic acid / 0.5 h / Ambient temperature

11: 1.) isoamyl nitrite, 5.3N HCl; 2.) (i-Pr)2NEt / 1.) DMF/THF, -40 deg C, 0.5 h; 2.) DMF/THF, 24 h, pH 9

12: 74 percent / H₂ / 10percent Pd/C / methanol; H₂O; acetic acid / 2 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; isopentyl nitrite; platinum(IV) oxide; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 157487-57-5
(S)-7-(4-Amino-butyl)-2-phenoxymethyl-7,8,10,11,13,14,16,17,19,20-decahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecene-6,9,12,15,18,21-hexaone

Guidance literature:: Multi-step reaction with 11 steps

1: NBS, benzoyl-peroxide / CCl₄ / Heating

2: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

3: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

4: SOCl₂, DMF / 2 h / Ambient temperature

5: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

6: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

7: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

8: 99.5 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

9: 100 percent / 2.9N HCl / acetic acid / 0.5 h / Ambient temperature

10: 1.) isoamyl nitrite, 5.3N HCl; 2.) (i-Pr)2NEt / 1.) DMF/THF, -40 deg C, 0.5 h; 2.) DMF/THF, 24 h, pH 9

11: 74 percent / H₂ / 10percent Pd/C / methanol; H₂O; acetic acid / 2 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; isopentyl nitrite; platinum(IV) oxide; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;