[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester
CAS No.:149835-85-8
Molecular Formula:C₃₆H₄₁N₇O₉
Molecular Weight:715.763
Hs Code.:

[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

Synonyms:[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

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Chemical Property of [4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

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Technology Process of [4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

There total 11 articles about [4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 149835-85-8
[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 32.6 g / AcCl / Heating

2: NBS, benzoyl-peroxide / CCl₄ / Heating

3: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

4: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

5: SOCl₂, DMF / 2 h / Ambient temperature

6: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

7: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

8: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

9: 99.5 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

10: 100 percent / 2.9N HCl / acetic acid / 0.5 h / Ambient temperature

11: 1.) isoamyl nitrite, 5.3N HCl; 2.) (i-Pr)2NEt / 1.) DMF/THF, -40 deg C, 0.5 h; 2.) DMF/THF, 24 h, pH 9

With hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; isopentyl nitrite; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 149835-85-8
[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: NBS, benzoyl-peroxide / CCl₄ / Heating

2: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

3: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

4: SOCl₂, DMF / 2 h / Ambient temperature

5: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

6: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

7: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

8: 99.5 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

9: 100 percent / 2.9N HCl / acetic acid / 0.5 h / Ambient temperature

10: 1.) isoamyl nitrite, 5.3N HCl; 2.) (i-Pr)2NEt / 1.) DMF/THF, -40 deg C, 0.5 h; 2.) DMF/THF, 24 h, pH 9

With hydrogenchloride; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat; hydrogen; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; isopentyl nitrite; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 88071-91-4
5-bromomethyl-2-nitrobenzoic acid methyl ester

: 149835-85-8
[4-((S)-6,9,12,15,18,21-Hexaoxo-2-phenoxymethyl-6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21-hexadecahydro-5H-5,8,11,14,17,20-hexaaza-benzocyclononadecen-7-yl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: aq. NaOH, aliquat / CH₂Cl₂ / 5 h / Ambient temperature

2: 85 percent / aq. 4N KOH / methanol / 2 h / Ambient temperature

3: SOCl₂, DMF / 2 h / Ambient temperature

4: 89 percent / Et₃N / dimethylformamide / 1.) 0 deg C, 2 h; 2.) r.t.

5: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

6: DCC / CH₂Cl₂; dimethylformamide / 1.) from -10 deg C to 0 deg C, 2 h; 2.) r.t.

7: 99.5 percent / NH₂NH₂*H₂O / methanol / Ambient temperature

8: 100 percent / 2.9N HCl / acetic acid / 0.5 h / Ambient temperature

9: 1.) isoamyl nitrite, 5.3N HCl; 2.) (i-Pr)2NEt / 1.) DMF/THF, -40 deg C, 0.5 h; 2.) DMF/THF, 24 h, pH 9

With hydrogenchloride; potassium hydroxide; sodium hydroxide; thionyl chloride; Aliquat; hydrogen; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; isopentyl nitrite; platinum(IV) oxide; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;