2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

Base Information

Chemical Name:2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide
CAS No.:1598382-68-3
Molecular Formula:C₁₁H₁₀ClF₄NO₂
Molecular Weight:299.653
Hs Code.:

Synonyms:2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

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Chemical Property of 2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

Chemical Property:

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Technology Process of 2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

There total 5 articles about 2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1598382-67-2
(R)-2-amino-1-(4-fluoro-3-trifluoromethyl-phenyl)-ethanol

: 79-04-9
chloroacetyl chloride

: 1598382-68-3
2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; for 0.583333h; Cooling with ice;

Reference yield:

: 208173-24-4
1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanone

: 1598382-68-3
2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 5 h / Reflux

2: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 1.5 h / 20 °C

3: sodium azide / dimethyl sulfoxide / 3 h / 80 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 h

5: sodium hydrogencarbonate / dichloromethane; water / 0.58 h / Cooling with ice

With sodium azide; borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1598382-66-1
(R)-2-azido-1-(4-fluoro-3-trifluoromethylphenyl)-ethanol

: 1598382-68-3
2-chloro-N-[(R)-2-(4-fluoro-3-trifluoromethylphenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 h

2: sodium hydrogencarbonate / dichloromethane; water / 0.58 h / Cooling with ice

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In methanol; dichloromethane; water;