(R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

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Chemical Name:(R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester
CAS No.:1201196-47-5
Molecular Formula:C₂₅H₂₁ClF₄N₂O₄
Molecular Weight:524.899
Hs Code.:

Synonyms:(R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

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Chemical Property of (R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

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Technology Process of (R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

There total 1 articles about (R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 924717-67-9
2-acetoxy-2-(4-fluorophenyl)acetic acid

: 1201196-46-4
[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

: 1201196-47-5
(R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

Guidance literature:: 2-acetoxy-2-(4-fluorophenyl)acetic acid; [3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 18h;

With sodium carbonate; In 1,4-dioxane; dichloromethane; tert-butyl methyl ether; water;

Reference yield: 57.0%

: 1201196-47-5
(R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

: 1201196-45-3
(R,S)-N-(4-chloro-3-hydroxymethyl-phenyl)-2-(4-fluoro-phenyl)-2-hydroxy-N-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-acetamide

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 27.0%

: 67-56-1
methanol

: 1201196-47-5
(R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester

: 1201196-49-7
2-chloro-5-[2-(5-trifluoromethyl-pyridin-2-yl)-ethylamino]-benzoic acid methyl ester

Guidance literature:: methanol; (R,S)-acetic acid {(4-chloro-3-hydroxymethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-carbamoyl}-(4-fluoro-phenyl)-methyl ester; With calcium hypochlorite; acetic acid; at 20 ℃; for 72h; Molecular sieve; Darkness;

With sodium cyanide; manganese(IV) oxide; In methanol; at 20 ℃; for 18h;