(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

Base Information

Chemical Name:(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole
CAS No.:1314042-61-9
Molecular Formula:C₂₀H₂₄N₂O
Molecular Weight:308.423
Hs Code.:

Synonyms:(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

Chemical Property:

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Technology Process of (4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

There total 3 articles about (4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 814-68-6,25189-84-8
acryloyl chloride

: 155095-10-6
(4R,7S)-3-phenyl-4-methyl-7-isopropyl-4,5,6,7-tetrahydro-1H-indazole

: 1314042-61-9
(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

: 2-acryloyl-2-phenyl-l-menthopyrazole

Guidance literature:: With triethylamine; In toluene; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo2010632

Reference yield:

: 2216-51-5
(-)-menthol

: 1314042-61-9
(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

: 2-acryloyl-2-phenyl-l-menthopyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: silica gel; pyridinium chlorochromate / dichloromethane / 5 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: hydrogenchloride; hydrazine hydrate / methanol; water / 16 h / Reflux; Inert atmosphere

3.2: Inert atmosphere

4.1: triethylamine / toluene / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; silica gel; hydrazine hydrate; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene;
DOI:10.1021/jo2010632

Reference yield:

: 10458-14-7,14073-97-3,17627-49-5,7786-64-3
(2R,5S)-menthone

: 1314042-61-9
(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

: 2-acryloyl-2-phenyl-l-menthopyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; hydrazine hydrate / methanol; water / 16 h / Reflux; Inert atmosphere

2.2: Inert atmosphere

3.1: triethylamine / toluene / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrazine hydrate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; water; toluene;
DOI:10.1021/jo2010632