(4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

Base Information

Chemical Name:(4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole
CAS No.:1314042-77-7
Molecular Formula:C₂₈H₃₁N₃O₃
Molecular Weight:457.572
Hs Code.:

Synonyms:(4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

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Chemical Property of (4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

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Technology Process of (4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

There total 10 articles about (4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1314042-61-9
(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

: 91174-01-5
sodium [(benzyloxy)carbonyl]chloroamide

: 1314042-77-7
(4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

Guidance literature:: With (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane; at -20 ℃; for 36h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo2010632

Reference yield:

: 1314042-61-9
(4R,7S)-1-acryloyl-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

: 91174-01-5
sodium [(benzyloxy)carbonyl]chloroamide

: 1314042-77-7
(4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

: (4R,7S)-1-[{(2'R)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

Guidance literature:: With (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane; at 20 ℃; for 9h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo2010632

Reference yield:

: 155095-12-8
(3R,6S)-2-Benzoyl-3-methyl-6-isopropylcyclohexanone

: 1314042-77-7
(4R,7S)-1-[{(2'S)-(1'-benzyloxycarbonyl)aziridin-2'-yl}carbonyl]-7-isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-indazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; hydrazine hydrate / methanol; water / 16 h / Reflux; Inert atmosphere

1.2: Inert atmosphere

2.1: triethylamine / toluene / 2 h / 20 °C / Inert atmosphere

3.1: (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide / dichloromethane / 36 h / -20 °C / Inert atmosphere

With hydrogenchloride; hydrazine hydrate; triethylamine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In methanol; dichloromethane; water; toluene;
DOI:10.1021/jo2010632