methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

Base Information

Chemical Name:methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate
CAS No.:1356113-03-5
Molecular Formula:C₂₈H₃₀FNO₇S
Molecular Weight:543.613
Hs Code.:

Synonyms:methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

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Chemical Property of methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

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Technology Process of methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

There total 7 articles about methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49777-66-4
1-(3-dihydroxyboranyl-furan-2-yl)-ethanone

: 1286181-33-6
(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-hydroxybenzoate

: 1356113-03-5
methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

Guidance literature:: With caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 65 ℃; for 1h; Inert atmosphere;

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1356113-03-5
methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

2: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

3: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

With aluminum (III) chloride; caesium carbonate; N,N-dimethyl-aniline; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1286179-94-9
methyl 3-bromo-6-bromomethyl-2-methoxybenzoate

: 1356113-03-5
methyl 3-(2-acetylfuran-3-yl)-6-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylmethyl]-2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / 20 - 80 °C

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / Inert atmosphere; Reflux

3.1: aluminum (III) chloride; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C

4.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

With aluminum (III) chloride; potassium carbonate; caesium carbonate; N,N-dimethyl-aniline; cesium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;