N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide
• CAS No.: 1365544-25-7
• Molecular Formula: C₁₁H₉F₃N₂O₄S
• Molecular Weight: 322.265

Synonyms:N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Chemical Property of N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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Technology Process of N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

There total 5 articles about N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene (1365544-29-1) + trifluoroacetic anhydride (407-25-0) → N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365544-25-7)

Guidance literature:

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene; With potassium carbonate; In dichloromethane; water; at 20 ℃; for 1h;

trifluoroacetic anhydride; With triethylamine; In dichloromethane; at 20 - 25 ℃; for 0.833333h;

Reference yield:

para-nitrobenzenethiol (1849-36-1) → N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365544-25-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.5 h / 30 °C

1.2: 8 h / 135 - 140 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C

2.2: 14.25 h / 20 - 25 °C

3.1: potassium carbonate; Oxone / methanol; sulfolane; water / 1 h / 25 °C / pH 10

4.1: acetonitrile / 16 h / 20 °C

5.1: potassium carbonate / water; dichloromethane / 1 h / 20 °C

5.2: 0.83 h / 20 - 25 °C

With Oxone; sodium hydride; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; sulfolane; methanol; dichloromethane; water; acetonitrile; mineral oil;

Reference yield:

1-(cyclopropylsulphanyl)-4-nitrobenzene (851008-48-5) → N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365544-25-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C

1.2: 14.25 h / 20 - 25 °C

2.1: potassium carbonate; Oxone / methanol; sulfolane; water / 1 h / 25 °C / pH 10

3.1: acetonitrile / 16 h / 20 °C

4.1: potassium carbonate / water; dichloromethane / 1 h / 20 °C

4.2: 0.83 h / 20 - 25 °C

With Oxone; sodium hydride; potassium carbonate; In tetrahydrofuran; sulfolane; methanol; dichloromethane; water; acetonitrile; mineral oil;

upstream raw materials:

N-[cyclopropyl(4-nitrophenyl)-lambda⁴-sulphanylidene]-2,2,2-trifluoroacetamide

cyclopropyl(imino)(4-nitrophenyl)-λ⁶-sulfanone

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene

trifluoroacetic anhydride

Downstream raw materials:

N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

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