4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

Base Information

Chemical Name:4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane
CAS No.:148517-62-8
Molecular Formula:C₁₈H₂₀O₄
Molecular Weight:300.354
Hs Code.:

Synonyms:4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

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Chemical Property of 4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

Chemical Property:

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Technology Process of 4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

There total 8 articles about 4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 148517-61-7
4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

: 148517-62-8
4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

Guidance literature:: With potassium fluoride; sodium tetrahydroborate; 18-crown-6 ether; In acetonitrile; for 120h; Heating;
DOI:10.1021/jo00064a017

Reference yield:

: 61441-09-6
methyl 6-bromo-1,3-benzodioxole-5-carboxylate

: 148517-62-8
4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / diethyl ether / 9 °C

2: 1) NaH / 1) THF, RT, 5.0 h, 2) THF, RT, overnight

3: 1) n-BuLi / 1) THF, -78 deg C, 1.75 h, 2)THF, -78 deg C, overnight

4: 70 percent / KF, NaBH₄, 18-crown-6 / acetonitrile / 120 h / Heating

With potassium fluoride; sodium tetrahydroborate; n-butyllithium; 18-crown-6 ether; sodium hydride; In diethyl ether; acetonitrile;
DOI:10.1021/jo00064a017

Reference yield:

6-bromopiperonylic acid: 60546-62-5
6-bromopiperonylic acid

: 148517-62-8
4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂SO₄ / methanol / 72 h / Heating

2: 80 percent / diethyl ether / 9 °C

3: 1) NaH / 1) THF, RT, 5.0 h, 2) THF, RT, overnight

4: 1) n-BuLi / 1) THF, -78 deg C, 1.75 h, 2)THF, -78 deg C, overnight

5: 70 percent / KF, NaBH₄, 18-crown-6 / acetonitrile / 120 h / Heating

With potassium fluoride; sodium tetrahydroborate; n-butyllithium; 18-crown-6 ether; sulfuric acid; sodium hydride; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/jo00064a017