4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

Base Information

Chemical Name:4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol
CAS No.:148517-61-7
Molecular Formula:C₂₄H₃₄O₅Si
Molecular Weight:430.616
Hs Code.:

Synonyms:4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

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Chemical Property of 4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

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Technology Process of 4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

There total 7 articles about 4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromopiperonylic acid: 60546-62-5
6-bromopiperonylic acid

: 148517-61-7
4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂SO₄ / methanol / 72 h / Heating

2: 80 percent / diethyl ether / 9 °C

3: 1) NaH / 1) THF, RT, 5.0 h, 2) THF, RT, overnight

4: 1) n-BuLi / 1) THF, -78 deg C, 1.75 h, 2)THF, -78 deg C, overnight

With n-butyllithium; sulfuric acid; sodium hydride; In methanol; diethyl ether;
DOI:10.1021/jo00064a017

Reference yield:

: 61441-09-6
methyl 6-bromo-1,3-benzodioxole-5-carboxylate

: 148517-61-7
4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / diethyl ether / 9 °C

2: 1) NaH / 1) THF, RT, 5.0 h, 2) THF, RT, overnight

3: 1) n-BuLi / 1) THF, -78 deg C, 1.75 h, 2)THF, -78 deg C, overnight

With n-butyllithium; sodium hydride; In diethyl ether;
DOI:10.1021/jo00064a017

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 148517-61-7
4'-(tert-butyldimethylsiloxy)-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)benzhydrol

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / KMnO₄ / 2-methyl-propan-2-ol; H₂O / 83 °C

2: 95 percent / H₂SO₄ / methanol / 72 h / Heating

3: 80 percent / diethyl ether / 9 °C

4: 1) NaH / 1) THF, RT, 5.0 h, 2) THF, RT, overnight

5: 1) n-BuLi / 1) THF, -78 deg C, 1.75 h, 2)THF, -78 deg C, overnight

With potassium permanganate; n-butyllithium; sulfuric acid; sodium hydride; In methanol; diethyl ether; water; tert-butyl alcohol;
DOI:10.1021/jo00064a017