Gly-Ni-PABP

Base Information

• Chemical Name: Gly-Ni-PABP
• CAS No.: 124302-98-3
• Molecular Formula: C₂₁H₁₅N₃O₃*Ni
• Molecular Weight: 416.058
• Mol file: 124302-98-3.mol

Synonyms:Gly-Ni-PABP

Chemical Property of Gly-Ni-PABP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Gly-Ni-PABP

There total 5 articles about Gly-Ni-PABP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide (124522-52-7) + glycine (56-40-6,18875-39-3,25718-94-9) + nickel(II) nitrate → (N-{phenyl[2-(pyridine-2-carboxamido)phenyl]methylidene}glycinato-N,N',N'',O)nickel(II) (124302-98-3)

Guidance literature:

With potassium hydroxide; sodium methylate; In methanol; glycine, Ni(NO3)2 and amide were reacted in presence of KOH or MeONa in methanol; chromd. or crystd. from CHCl3;

DOI:10.1021/ja035465e

Reference yield: 91.0%

nickel(II) nitrate hexahydrate + pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide (124522-52-7) + glycine (56-40-6,18875-39-3,25718-94-9) → (N-{phenyl[2-(pyridine-2-carboxamido)phenyl]methylidene}glycinato-N,N',N'',O)nickel(II) (124302-98-3)

Guidance literature:

With sodium methylate; In methanol; condensation of C19H14N2O2, Ni(NO3)2*6H2O, and glycine under reflux for 20 min; crystd. from CHCl3; detd. by elem. anal., NMR, UV, IR;

DOI:10.1002/1521-3773(20010518)40:10<1948::AID-ANIE1948>3.0.CO;2-O

Reference yield:

pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide (124522-52-7) + glycine (56-40-6,18875-39-3,25718-94-9) + nickel dichloride (83864-14-6) → (N-{phenyl[2-(pyridine-2-carboxamido)phenyl]methylidene}glycinato-N,N',N'',O)nickel(II) (124302-98-3)

Guidance literature:

With sodium hydroxide; In methanol; at 20 - 60 ℃; for 16h;

DOI:10.1016/j.jfluchem.2019.109376

upstream raw materials:

pyridine-2-carboxylic acid(2-benzoyl-phenyl)-amide

glycine

2-Picolinic acid

nickel dichloride

Downstream raw materials:

[Ni(NC₅H₄C(O)NC₆H₄C(C₆H₅)NCH(CH₂C₆H₃(OCH₂O))C(O)O)]

[Ni(NC₅H₄C(O)NC₆H₄C(C₆H₅)NCH(CH₂CHCH₂)C(O)O)]

[Ni(NC₅H₄C(O)NC₆H₄C(C₆H₅)NC(CH₂CHCH₂)2C(O)O)]

[Ni(NC₅H₄C(O)NC₆H₄C(C₆H₅)NCH(CH(CH₃)2)C(O)O)]

Refernces

• 1、 Belokon, Yuri N.,Bespalova, Natalia B.,Churkina, Tatiana D.,Cisarova, Ivana,Ezernitskaya, Marina G.,Harutyunyan, Syuzanna R.,Hrdina, Radim,Kagan, Henri B.,Kocovsky, Pavel,Kochetkov, Konstantin A.,Larionov, Oleg V.,Lyssenko, Konstantin A.,North, Michael,Polasek, Miroslav,Peregudov, Alexander S.,Prisyazhnyuk, Vladimir V.,Vyskocil, Stepan. "Synthesis of α-Amino Acids via Asymmetric Phase Transfer-Catalyzed Alkylation of Achiral Nickel(II) Complexes of Glycine-Derived Schiff Bases". . p. 12860 - 12871. Retrieved 2007/10/03.