succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate

Base Information

• Chemical Name: succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate
• CAS No.: 1193117-31-5
• Molecular Formula: C₁₇H₁₉N₃O₁₀
• Molecular Weight: 425.352
• Mol file: 1193117-31-5.mol

Synonyms:succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate

Chemical Property of succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate

There total 3 articles about succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoic acid (1193117-30-4) → succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate (1193117-31-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1246/bcsj.82.997

Reference yield:

4,5-dimethoxy-2-nitrobenzyl (4-nitrophenyl) carbonate (163518-08-9) → succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate (1193117-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / N,N-dimethyl acetamide / 48 h / 20 °C

2: water; tetraethylammonium hydroxide / ethanol; chloroform

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 72 h / 20 °C

With dmap; water; tetraethylammonium hydroxide; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide;

DOI:10.1246/bcsj.82.997

Reference yield:

6-nitroveratryl alcohol (1016-58-6) → succinimidyl 3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoate (1193117-31-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl acetamide / 48 h / 20 °C

2: dmap / N,N-dimethyl acetamide / 48 h / 20 °C

3: water; tetraethylammonium hydroxide / ethanol; chloroform

4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 72 h / 20 °C

With dmap; water; tetraethylammonium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide;

DOI:10.1246/bcsj.82.997

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3-[(4,5-dimethoxy-2-nitrobenzyloxycarbonyl)amino]propanoic acid

4,5-dimethoxy-2-nitrobenzyl (4-nitrophenyl) carbonate

6-nitroveratryl alcohol