5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

Base Information

Chemical Name:5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde
CAS No.:1418203-75-4
Molecular Formula:C₃₁H₃₅NO₅
Molecular Weight:501.623
Hs Code.:

Synonyms:5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

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Chemical Property of 5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

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Technology Process of 5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

There total 7 articles about 5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401791-63-6
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

: 1418203-75-4
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

Guidance literature:: With borane-THF; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.08.061

Reference yield:

: 1259391-05-3
benzyl 5-hydroxymethyl-2-propoxybenzoate

: 1418203-75-4
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / diethyl ether / 2 h / 0 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

3: 10% Pd/C; hydrogen / ethyl acetate / 1500.15 - 2250.23 Torr

4: borane-THF / 0 - 20 °C

With borane-THF; 10% Pd/C; hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; diethyl ether; ethyl acetate;
DOI:10.1016/j.bmc.2012.08.061

Reference yield:

: 1259391-04-2
benzyl 2-propoxy-5-formylsalicylate

: 1418203-75-4
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 2 h / 0 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

4: 10% Pd/C; hydrogen / ethyl acetate / 1500.15 - 2250.23 Torr

5: borane-THF / 0 - 20 °C

With sodium tetrahydroborate; borane-THF; 10% Pd/C; hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate;
DOI:10.1016/j.bmc.2012.08.061