5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

Base Information

Chemical Name:5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid
CAS No.:1401791-63-6
Molecular Formula:C₃₁H₃₃NO₆
Molecular Weight:515.606
Hs Code.:

Synonyms:5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

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Chemical Property of 5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

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Technology Process of 5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

There total 6 articles about 5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401791-62-5
benzyl 5-((R)-2-benzyl-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-oxopropyl)-2-propoxybenzoate

: 1401791-63-6
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

Guidance literature:: With 10% Pd/C; hydrogen; In ethyl acetate; under 1500.15 - 2250.23 Torr;
DOI:10.1016/j.bmc.2012.08.061

Reference yield:

: 1259391-05-3
benzyl 5-hydroxymethyl-2-propoxybenzoate

: 1401791-63-6
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus tribromide / diethyl ether / 2 h / 0 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

3: 10% Pd/C; hydrogen / ethyl acetate / 1500.15 - 2250.23 Torr

With 10% Pd/C; hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; diethyl ether; ethyl acetate;
DOI:10.1016/j.bmc.2012.08.061

Reference yield:

: 1259391-04-2
benzyl 2-propoxy-5-formylsalicylate

: 1401791-63-6
5-((R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-(cyclohexylmethyl)-3-oxopropyl)-2-propoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 2 h / 0 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / -50 - -15 °C / Inert atmosphere

4: 10% Pd/C; hydrogen / ethyl acetate / 1500.15 - 2250.23 Torr

With sodium tetrahydroborate; 10% Pd/C; hydrogen; sodium hexamethyldisilazane; phosphorus tribromide; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate;
DOI:10.1016/j.bmc.2012.08.061