4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Base Information

Chemical Name:4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid
CAS No.:1350836-72-4
Molecular Formula:C₂₈H₄₂F₂N₂O₁₂P₂
Molecular Weight:698.592
Hs Code.:

4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Synonyms:4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Suppliers and Price of 4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

There total 3 articles about 4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: tetrabutylammonium alendronate

: 1350836-80-4
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

: 1350836-72-4
4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Guidance literature:: tetrabutylammonium alendronate; ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate; With N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h;

In water;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

: 1350836-72-4
4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide / 2 h / 20 °C

5.2: Amberlite IR-120 ion exchange resin H⁽¹⁺⁾ form

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 1350836-72-4
4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: Amberlite IR-120 ion exchange resin H⁽¹⁺⁾ form

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.024