ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

Base Information

Chemical Name:ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate
CAS No.:1350836-80-4
Molecular Formula:C₃₀H₃₄F₂N₂O₈
Molecular Weight:588.605
Hs Code.:

Synonyms:ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

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Chemical Property of ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

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Technology Process of ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

There total 2 articles about ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 7693-46-1
4-Nitrophenyl chloroformate

: 1350836-80-4
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: 1365735-34-7
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl 2-acetoxybenzoate

: 1350836-80-4
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol / 3.67 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.024

Reference yield: 33.0%

: tetrabutylammonium alendronate

: 1350836-80-4
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate

: 1350836-72-4
4-(((R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yloxy)carbonylamino)-1-hydroxybutane-1,1-diphosphoric acid

Guidance literature:: tetrabutylammonium alendronate; ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-((4-nitrophenoxy)-carbonyloxy)-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)-heptanoate; With N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h;

In water;
DOI:10.1016/j.bmc.2012.01.024