ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

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Chemical Name:ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate
CAS No.:1350836-65-5
Molecular Formula:C₂₃H₃₁F₂NO₄
Molecular Weight:423.5
Hs Code.:

Synonyms:ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

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Chemical Property of ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

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Technology Process of ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

There total 12 articles about ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1365735-36-9
(R,E)-4-((R)-1-(7-ethoxy-7-oxoheptyl)-5-oxopyrrolidin-2-yl)-1,1-difluoro-1-phenylbut-3-en-2-yl ((4-nitrophenoxy)-carbonyloxy)benzoate

: 100-46-9
benzylamine

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 2037-99-2
3-benzyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-(4-iodophenyl)but-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: With sodium tetrahydroborate; sodium borodeuteride; palladium diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.6b00951

Reference yield:

: ethyl 2,2-difluoro-2-(4-iodophenyl)acetate

: 1350836-65-5
ethyl 7-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: 4 h / -78 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 6 h / 0 - 50 °C

3.1: triethylamine; formic acid; [((1S,2S)-2-amino-1,2-diphenylethyl)(tosyl)amido](p-cymene)(pyridine)ruthenium(II) tetrafluoroborate / dichloromethane / 24 h / -5 °C

4.1: palladium diacetate; sodium tetrahydroborate; sodium borodeuteride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; formic acid; sodium borodeuteride; [((1S,2S)-2-amino-1,2-diphenylethyl)(tosyl)amido](p-cymene)(pyridine)ruthenium(II) tetrafluoroborate; palladium diacetate; sodium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.6b00951