N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide
CAS No.:1201842-34-3
Molecular Formula:C₂₆H₁₈ClFN₄O₃S
Molecular Weight:520.971
Hs Code.:

Synonyms:N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

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Chemical Property of N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Chemical Property:

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Technology Process of N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

There total 6 articles about N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201841-63-5
N-(2-chloro-5-(4-chloroquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

: 163105-90-6
2-methoxypyridin-3-yl-boronic acid

: 1201842-34-3
N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Guidance literature:: With sodium carbonate; Pd fibrecat PPh; In 1,4-dioxane; at 120 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1201842-34-3
N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 24 h / 23 °C

2: sodium carbonate / Pd fibrecat PPh / 1,4-dioxane / 0.33 h / 120 °C / microwave irradiation

3: sodium carbonate / Pd fibrecat PPh / 1,4-dioxane / 0.33 h / 120 °C / microwave irradiation

With pyridine; sodium carbonate; Pd fibrecat PPh; In 1,4-dioxane;

Reference yield:

: 65340-70-7
6-bromo-4-chloroquinoline

: 1201842-34-3
N-(2-chloro-5-(4-(2-methoxy-3-pyridinyl)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

2: sodium carbonate / Pd fibrecat PPh / 1,4-dioxane / 0.33 h / 120 °C / microwave irradiation

3: sodium carbonate / Pd fibrecat PPh / 1,4-dioxane / 0.33 h / 120 °C / microwave irradiation

With potassium acetate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane;