2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

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Chemical Name:2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide
CAS No.:628279-14-1
Molecular Formula:C₂₁H₂₇N₅O₄
Molecular Weight:413.476
Hs Code.:

Synonyms:2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

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Chemical Property of 2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

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Technology Process of 2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

There total 5 articles about 2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18699-02-0
4-acetamidophenylacetic acid

: 628278-99-9
3-allyl-5,6-diamino-1-butyl-1H-pyrimidine-2,4-dione

: 628279-14-1
2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

Guidance literature:: 3-allyl-5,6-diamino-1-butyl-1H-pyrimidine-2,4-dione; With 1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

4-acetamidophenylacetic acid; With dmap; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00722-4

Reference yield:

: 628278-98-8
3-allyl-6-amino-1-butyl-1H-pyrimidine-2,4-dione

: 628279-14-1
2-(4-Acetylamino-phenyl)-N-(3-allyl-6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaNO₂; HOAc

1.2: Na₂S₂O₄; NH₄OH / 85 - 95 °C

2.1: EDCI; imidazole

2.2: DMAP / dimethylformamide

With 1H-imidazole; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite;
DOI:10.1016/S0960-894X(03)00722-4