5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine
CAS No.:1259279-56-5
Molecular Formula:C₁₉H₁₄F₂N₄O₂S₂
Molecular Weight:432.475
Hs Code.:

Synonyms:5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

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Chemical Property of 5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

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Technology Process of 5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

There total 10 articles about 5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87789-51-3
2-chloro-5-fluoro-4-methylthiopyrimidine

: 1259279-56-5
5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

Guidance literature:: With sodium carbonate; Pd(PPh₃)4; In 1,2-dimethoxyethane; water;

Reference yield:

: potassium trifluoro(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)borate

: 87789-51-3
2-chloro-5-fluoro-4-methylthiopyrimidine

: 1259279-56-5
5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water;

Reference yield:

: 1417421-99-8
3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1259279-56-5
5-fluoro-3-(5-fluoro-4-methylsulfanyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: sodium carbonate / water; 1,2-dimethoxyethane / 0.33 h / Inert atmosphere

2.2: Inert atmosphere; Reflux

With potassium acetate; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water;