1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane
• CAS No.: 306776-77-2
• Molecular Formula: C₂₄H₄₀N₄O₄
• Molecular Weight: 448.606
• Mol file: 306776-77-2.mol

Synonyms:1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane

Chemical Property of 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane

There total 3 articles about 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1,4,7,10-tetraazacyclododecan (294-90-6) + α-bromoglutaric acid 1-tert-butyl ester 5-benzyl ester (306776-74-9) → 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane (306776-77-2)

Guidance literature:

In chloroform; at 20 ℃; for 48h;

DOI:10.1016/S0960-894X(00)00413-3

Reference yield:

tert-Butyl 2,2,2-trichloroacetimidate (98946-18-0) → 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane (306776-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / DMA; BF₃*OEt₂ / cyclohexane; CHCl₃ / 72 h / 20 °C

2: 83 percent / CHCl₃ / 48 h / 20 °C

With boron trifluoride diethyl etherate; 2,4-dichlorophenoxyacetic acid dimethylamine; In chloroform; cyclohexane; 1: Alkylation / 2: Alkylation;

DOI:10.1016/S0960-894X(00)00413-3

Reference yield:

L-glutamic acid γ-benzyl ester (1676-73-9,25014-27-1) → 1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-1,4,7,10-tetraazacyclododecane (306776-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / DMA; BF₃*OEt₂ / cyclohexane; CHCl₃ / 72 h / 20 °C

2: 83 percent / CHCl₃ / 48 h / 20 °C

With boron trifluoride diethyl etherate; 2,4-dichlorophenoxyacetic acid dimethylamine; In chloroform; cyclohexane; 1: Alkylation / 2: Alkylation;

DOI:10.1016/S0960-894X(00)00413-3

upstream raw materials:

1,4,7,10-tetraazacyclododecan

α-bromoglutaric acid 1-tert-butyl ester 5-benzyl ester

tert-Butyl 2,2,2-trichloroacetimidate

L-glutamic acid γ-benzyl ester

Downstream raw materials:

(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10-tetraazacyclododecane