methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

Base Information

Chemical Name:methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid
CAS No.:936755-53-2
Molecular Formula:C₁₈H₁₆F₂N₂O₅
Molecular Weight:378.332
Hs Code.:

Synonyms:methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

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Chemical Property of methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

Chemical Property:

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Technology Process of methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

There total 5 articles about methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936755-52-1
2,2-difluoro-2-(4-(methoxycarbonyl)phenyl)acetic acid

: 7466-54-8
2-methoxybenzoylhydrazine

: 936755-53-2
methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

Guidance literature:: With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 302912-31-8
ethyl-4-cyanobenzoylformate

: 936755-53-2
methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; water / 16 h / Heating / reflux

2: thionyl chloride / 16 h / 20 °C

3: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 16 h / 20 °C

4: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 6051-67-8
1,4-benzenemonoketodicarboxylic acid

: 936755-53-2
methyl 4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 16 h / 20 °C

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 16 h / 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With sodium hydroxide; thionyl chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane;