2-Phenyl-2-phenylthiopropannitril

Base Information

• Chemical Name: 2-Phenyl-2-phenylthiopropannitril
• CAS No.: 54835-27-7
• Molecular Formula: C₁₅H₁₃NS
• Molecular Weight: 239.341
• Mol file: 54835-27-7.mol

Synonyms:2-Phenyl-2-phenylthiopropannitril

Chemical Property of 2-Phenyl-2-phenylthiopropannitril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenyl-2-phenylthiopropannitril

There total 5 articles about 2-Phenyl-2-phenylthiopropannitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

α-(phenylthio)-benzyl cyanide (32121-59-8) + methyl iodide (74-88-4) → 2-Phenyl-2-phenylthiopropannitril (54835-27-7)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; Ambient temperature;

DOI:10.1246/cl.1985.1149

Reference yield: 90.0%

phenyl thiocyanate (5285-87-0) + acetophenone p-toluenesulfonylhydrazone (4545-21-5) → 2-Phenyl-2-phenylthiopropannitril (54835-27-7)

Guidance literature:

With copper(I) thiocyanate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c7sc02867a

Reference yield:

diphenyldisulfane (882-33-7) + 1-phenylethyl cyanide (1823-91-2) → 2-Phenyl-2-phenylthiopropannitril (54835-27-7)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran;

DOI:10.1055/s-1978-24743

upstream raw materials:

benzenesulfenyl chloride

1-phenylethyl cyanide

α-(phenylthio)-benzyl cyanide

methyl iodide

Downstream raw materials:

α-benzyl-α-methylphenylacetonitrile