1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene

Base Information

• Chemical Name: 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene
• CAS No.: 186963-29-1
• Molecular Formula: C₁₆H₂₄O₇
• Molecular Weight: 328.362
• Mol file: 186963-29-1.mol

Synonyms:1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene

Chemical Property of 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene

There total 3 articles about 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2-methoxyethoxy)acetyl chloride (16024-55-8) + 4-(2-(2-methoxyethoxy)ethoxy)phenol (30311-35-4) → 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene (186963-29-1)

Guidance literature:

With triethylamine; In dichloromethane; at -5 - 20 ℃; for 21h;

DOI:10.1021/ja962937z

Reference yield:

2-(2-methoxyethoxy)acetic acid (16024-56-9) → 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene (186963-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / oxalyl chloride; pyridine / toluene / 24 h / 20 °C

2: 90 percent / Et₃N / CH₂Cl₂ / 21 h / -5 - 20 °C

With pyridine; oxalyl dichloride; triethylamine; In dichloromethane; toluene; 1: Substitution / 2: Esterification;

DOI:10.1021/ja962937z

Reference yield:

C36H32N4(4+)*C16H24O7*4F6P(1-) → cyclobis(paraquat-1,4-phenylene) tetrakis(hexafluorophosphate) (117271-77-9) + 1-[2-(2-methoxyethoxy)ethoxy]-4-[[(2-methoxyethoxy)methylene]carboxy]benzene (186963-29-1)

Guidance literature:

In [D₃]acetonitrile; at 25 ℃; Equilibrium constant;

DOI:10.1021/ja962937z

upstream raw materials:

2-(2-methoxyethoxy)acetyl chloride

4-(2-(2-methoxyethoxy)ethoxy)phenol

2-(2-methoxyethoxy)acetic acid