R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

Base Information

Chemical Name:R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide
CAS No.:1005459-79-9
Molecular Formula:C₂₆H₂₀ClF₄N₃O
Molecular Weight:501.911
Hs Code.:

Synonyms:R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

There total 3 articles about R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1005460-16-1
2,4,6-trifluorobenzimidamide acetate

: 84194-36-5
2-chloro-4-fluorobenzaldehyde

: 63664-41-5
(R)-(+)-N-(1-phenylethyl)-3-oxobutyramide

: 1005459-79-9
R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

: R,S-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

Guidance literature:: 2-chloro-4-fluorobenzaldehyde; (R)-(+)-N-(1-phenylethyl)-3-oxobutyramide; With piperidine; acetic acid; at 20 ℃; for 24h;

2,4,6-trifluorobenzimidamide acetate; With sodium acetate; for 20h; Reflux;
DOI:10.3390/molecules180911144

Reference yield:

: 1005460-16-1
2,4,6-trifluorobenzimidamide acetate

: 84194-36-5
2-chloro-4-fluorobenzaldehyde

: 63664-41-5
(R)-(+)-N-(1-phenylethyl)-3-oxobutyramide

: 1005459-79-9
R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

Guidance literature:: 2-chloro-4-fluorobenzaldehyde; (R)-(+)-N-(1-phenylethyl)-3-oxobutyramide; In ethanol; at 20 ℃; for 48h;

2,4,6-trifluorobenzimidamide acetate; In ethanol; Heating / reflux;

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1005459-79-9
R,R-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

: R,S-N-(1-phenylethyl)-4-(2-chloro-4-fluorophenyl)-2-(2,4,6-trifluorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine

2.1: acetic acid; piperidine / 24 h / 20 °C

2.2: 20 h / Reflux

With piperidine; acetic acid; triethylamine; 2.1: |Knoevenagel Condensation;
DOI:10.3390/molecules180911144