pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

Base Information

Chemical Name:pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester
CAS No.:243658-69-7
Molecular Formula:C₂₂H₂₂N₂O₄
Molecular Weight:378.428
Hs Code.:

pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4<i>H</i>-pyridin-1-yl)-ethyl ester

Synonyms:pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

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Chemical Property of pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

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Technology Process of pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

There total 4 articles about pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 98-98-6
2-Picolinic acid

: 210244-51-2
1-[2'-(hydroxy)ethyl]-2-ethyl-3-benzyloxy-4(1H)-pyridinone

: 243658-69-7
pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;
DOI:10.1211/0022357991772655

Reference yield:

: 4940-11-8
2-ethyl-3-hydroxy-4-pyranone

: 243658-69-7
pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84.8 percent / sodium hydroxide / methanol; H₂O / 6 h / Heating

2: 60 percent / sodium hydroxide / ethanol; H₂O / pH 13.5 / Heating

3: 82 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water; 1: Etherification / 2: Condensation / 3: Esterification;
DOI:10.1211/0022357991772655

Reference yield:

: 100-44-7
benzyl chloride

: 243658-69-7
pyridine-2-carboxylic acid 2-(3-benzyloxy-2-ethyl-4-oxo-4H-pyridin-1-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84.8 percent / sodium hydroxide / methanol; H₂O / 6 h / Heating

2: 60 percent / sodium hydroxide / ethanol; H₂O / pH 13.5 / Heating

3: 82 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 20 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; water; 1: Etherification / 2: Condensation / 3: Esterification;
DOI:10.1211/0022357991772655