3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde
• CAS No.: 5547-00-2
• Molecular Formula: C₁₅H₁₇N₃O₂
• Molecular Weight: 271.319
• Mol file: 5547-00-2.mol

Synonyms:3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde

Chemical Property of 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde 95%+ ^*data from reagent suppliers

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Technology Process of 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde

There total 4 articles about 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

morpholine (110-91-8,99108-56-2) + 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) → 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde (5547-00-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 20h;

DOI:10.3987/COM-07-11260

Reference yield: 10.0%

morpholine (110-91-8,99108-56-2) + 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde (5547-00-2) + 5-dimethylamino-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (5499-69-4)

Guidance literature:

With potassium hydroxide; at 120 ℃; for 5h;

DOI:10.1081/SCC-120030741

Reference yield:

edaravone (89-25-8) → 3-methyl-5-morpholin-4-yl-1-phenyl-1H-pyrazole-4-carbaldehyde (5547-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Heating

2: triethylamine / ethanol / Reflux

With triethylamine; trichlorophosphate; In ethanol; 1: |Vilsmeier-Haack Formylation;

DOI:10.14233/ajchem.2014.16002

upstream raw materials:

morpholine

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

N,N-dimethyl-formamide

phenylhydrazine

Downstream raw materials:

(+/-)-2,2,3'-trimethyl-1'-phenyl-1',4',5a',6',8',9'-hexahydrospiro[1,3-dioxane-5,5'-pyrazolo[4',3':5,6]pyrido[2,1-c][1,4]oxazine]-4,6-dione

(+/-)-1',3,3'-trimethyl-1-phenyl-1,4,5a,6,8,9-hexahydro-2'H-spiro[pyrazolo[4',3':5,6]pyrido[2,1-c][1,4]oxazine-5,5'-pyrimidine]-2',4',6'(1'H,3'H)-trione

3-methyl-1-phenyl-1,4,5a,6,8,9-hexahydro-5H-pyrazolo[4',3':5,6]pyrido[2,1-c][1,4]oxazine-5,5-dicarbonitrile

2-(3-methyl-5-morpholino-1-phenyl-1H-pyrazol-4-ylmethylene)malononitrile

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