1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

Base Information

Chemical Name:1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone
CAS No.:1402048-44-5
Molecular Formula:C₄₁H₆₁N₃O₄S₂
Molecular Weight:724.085
Hs Code.:

Synonyms:1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

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Chemical Property of 1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

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Technology Process of 1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

There total 7 articles about 1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1402049-35-7
acetic acid 2-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-ylpropoxy)phenyl-sulfanyl]-piperidin-1-yl}-2-oxo-ethyl ester

: 1402048-44-5
1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

Guidance literature:: acetic acid 2-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-ylpropoxy)phenyl-sulfanyl]-piperidin-1-yl}-2-oxo-ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 1402048-44-5
1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / methanol / 20 h / 45 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 85 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

5: isopropyl alcohol; potassium hydroxide / 24 h / 85 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

7: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With hydrogenchloride; water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1402048-44-5
1-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-pyrazol-1-yl-propoxy)phenylsulfanyl]piperidin-1-yl}-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / methanol / 20 h / 45 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 85 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

5: isopropyl alcohol; potassium hydroxide / 24 h / 85 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

7: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With hydrogenchloride; water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;