rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane

Base Information

• Chemical Name: rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane
• CAS No.: 1512854-02-2
• Molecular Formula: C₁₃H₁₉ClSi
• Molecular Weight: 238.832
• Mol file: 1512854-02-2.mol

Synonyms:rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane

Chemical Property of rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane

There total 1 articles about rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

phenylmagnesium chloride (100-59-4) + 3,3-dimethyl-allyl chloride (503-60-6) + chloromethylmethyldichlorosilane (1558-33-4) → rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane (1512854-02-2)

Guidance literature:

phenylmagnesium chloride; chloromethylmethyldichlorosilane; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1.5h;

3,3-dimethyl-allyl chloride; With magnesium; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 17h;

DOI:10.1021/om401070c

Reference yield: 75.0%

rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane (1512854-02-2) + sodium acetate (127-09-3) → rac-(acetoxymethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane (1512854-03-3)

Guidance literature:

With tetra-n-butylphosphonium chloride; In N,N-dimethyl-formamide; for 17h; Reflux;

DOI:10.1021/om401070c

Reference yield:

rac-(chloromethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane (1512854-02-2) → rac-(hydroxymethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane (1512854-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra-n-butylphosphonium chloride / N,N-dimethyl-formamide / 17 h / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; tetra-n-butylphosphonium chloride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/om401070c

upstream raw materials:

phenylmagnesium chloride

3,3-dimethyl-allyl chloride

chloromethylmethyldichlorosilane

Downstream raw materials:

rac-(acetoxymethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane

rac-(hydroxymethyl)methyl(3-methylbut-2-en-1-yl)phenylsilane

rac-3,6,6-trimethyl-3-phenyl-3-silatetrahydropyran