dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

Base Information

Chemical Name:dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate
CAS No.:1383604-57-6
Molecular Formula:C₃₀H₃₀N₂O₅S
Molecular Weight:530.645
Hs Code.:

Synonyms:dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

There total 8 articles about dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1383604-52-1
methyl 2-(4-methoxybenzyl)hydrazinecarboxylate

: 1383604-50-9
methyl 4-ethynyl-3-(thiophen-2-ylethynyl)benzoate

: 78-84-2
isobutyraldehyde

: 1383604-57-6
dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

Guidance literature:: With [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; AgOTf; acetic acid; at 50 ℃; for 7h;
DOI:10.1039/c2ob25298h

Reference yield:

: 356101-62-7
methyl 2-(4-methoxybenzylidene)hydrazinecarboxylate

: 1383604-57-6
dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C / Inert atmosphere

2: [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; AgOTf; acetic acid / 7 h / 50 °C

With [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; palladium 10% on activated carbon; AgOTf; hydrogen; acetic acid; In ethanol;
DOI:10.1039/c2ob25298h

Reference yield:

: 1150112-11-0
methyl 3-bromo-4-[(trimethylsilyl)ethynyl]benzoate

: 1383604-57-6
dimethyl 3-isopropyl-2-(4-methoxybenzyl)-4-(thiophen-2-yl)-2,3-dihydro-1H-benzo[g]indazole-1,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis(benzonitrile)palladium(ll) chloride; tri-tert-butyl phosphine; diisopropylamine / toluene / 7 h / 20 °C / Inert atmosphere

2: methanol; potassium carbonate / 1 h / 20 °C

3: [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; AgOTf; acetic acid / 7 h / 50 °C

With methanol; copper(l) iodide; bis(benzonitrile)palladium(ll) chloride; tri-tert-butyl phosphine; [1,3-bis(2,6-diisopropylphenyl)-1H-imidazol-2-(3H)-ylidene]gold(I)chloride; AgOTf; potassium carbonate; acetic acid; diisopropylamine; In toluene;
DOI:10.1039/c2ob25298h