2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine

Base Information

Chemical Name:2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine
CAS No.:102362-14-1
Molecular Formula:C₁₄H₁₃N₃O₂S
Molecular Weight:287.342
Hs Code.:
ChEMBL ID:CHEMBL43072
DSSTox Substance ID:DTXSID20556135,DTXSID50903310
Nikkaji Number:J1.551.461B

Synonyms:102362-14-1;CHEMBL43072;NoName_3955;SCHEMBL7289197;DTXSID20556135;DTXSID50903310;2-(2-methoxy-4-(methylsulfinyl)phenyl)imidazo[1,2-a]pyrazine;2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine;BDBM50212757

Suppliers and Price of 2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:287.07284784
Heavy Atom Count:20
Complexity:368

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)S(=O)C)C2=CN3C=CN=CC3=N2

Technology Process of 2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine

There total 10 articles about 2-[4-(Methanesulfinyl)-2-methoxyphenyl]imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 114552-59-9
2-<2-methoxy-4-(methylthio)phenyl>imidazo<1,2-a>pyrazine

: 102362-14-1
2-<2-methoxy-4-(methylsulfenyl)phenyl>imidazo<1,2-a>pyrazine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at -40 ℃; for 3h;
DOI:10.1021/jm00403a018

Reference yield:

: 372-20-3
3-fluorophenol

: 102362-14-1
2-<2-methoxy-4-(methylsulfenyl)phenyl>imidazo<1,2-a>pyrazine

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 75 percent / aluminium chloride / 160 - 180 °C

3: 92 percent / sodium hydride / dimethylformamide / 1 h / 0 °C

4: 55 percent / potassium hydroxide / dimethylformamide / 2 h / 0 °C

5: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h

6: 84 percent / bromine, acetic acid / CH₂Cl₂ / Ambient temperature

7: dimethylformamide / 48 h / 50 °C

8: 9 percent / aq. HCl / CH₂Cl₂ / 3 h / Heating

9: 32 percent / m-chloroperbenzoic acid / CHCl₃ / 3 h / -40 °C

With pyridine; hydrogenchloride; potassium hydroxide; aluminium trichloride; bromine; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a018

Reference yield:

: 1481-27-2
4-Fluoro-2-hydroxyacetophenone

: 102362-14-1
2-<2-methoxy-4-(methylsulfenyl)phenyl>imidazo<1,2-a>pyrazine

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / sodium hydride / dimethylformamide / 1 h / 0 °C

2: 55 percent / potassium hydroxide / dimethylformamide / 2 h / 0 °C

3: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h

4: 84 percent / bromine, acetic acid / CH₂Cl₂ / Ambient temperature

5: dimethylformamide / 48 h / 50 °C

6: 9 percent / aq. HCl / CH₂Cl₂ / 3 h / Heating

7: 32 percent / m-chloroperbenzoic acid / CHCl₃ / 3 h / -40 °C

With hydrogenchloride; potassium hydroxide; bromine; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a018