rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

Base Information

Chemical Name:rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one
CAS No.:1352419-11-4
Molecular Formula:C₁₂H₁₁BrF₃NO₃
Molecular Weight:354.123
Hs Code.:

Synonyms:rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

Chemical Property:

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Technology Process of rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

There total 5 articles about rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: 1213181-85-1
(2R)-2-amino-2-(3-bromophenyl)-propan-1-ol

: 1352419-11-4
rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

Guidance literature:: In di-isopropyl ether; at 0 - 70 ℃;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352419-11-4
rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2: hydrogenchloride / 96 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

5: di-isopropyl ether / 0 - 70 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonium chloride; In tetrahydrofuran; methanol; di-isopropyl ether; carbon dioxide; ammonia;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352419-11-4
rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 96 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

4: di-isopropyl ether / 0 - 70 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; methanol; di-isopropyl ether; carbon dioxide;