6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

Base Information

Chemical Name:6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline
CAS No.:351890-38-5
Molecular Formula:C₂₈H₂₇ClN₂O₅
Molecular Weight:506.986
Hs Code.:

Synonyms:6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

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Chemical Property of 6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

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Technology Process of 6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

There total 10 articles about 6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 119880-09-0
6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(chloromethyl)indoline

: 351890-38-5
6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

Guidance literature:: 6-(benzyloxy)-1-((tert-butyloxy)carbonyl)-3-(chloromethyl)indoline; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

5,6,7-trimethoxy-1H-indole-2-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1007/s12272-011-0302-1

Reference yield: 55.0%

: 366789-53-9
(3R/S)-6-benzyloxy-3-hydroxymethyl-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole

: 351890-38-5
6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

Guidance literature:: With tetrachloromethane; triphenylphosphine; In dichloromethane; at 40 ℃; for 5h;
DOI:10.1016/S0968-0896(01)00098-0

Reference yield: 51.5%

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 351890-37-4
6-benzyloxy-3-(chloromethyl)indoline

: 351890-38-5
6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1515/HC.2001.7.1.7