N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide
CAS No.:1221442-95-0
Molecular Formula:C₃₇H₃₈FN₅O₆
Molecular Weight:667.737
Hs Code.:

N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Synonyms:N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

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Chemical Property of N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

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Technology Process of N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

There total 7 articles about N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1221443-41-9
3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propyl methanesulfonate

: 1221443-49-7
N-(3-fluoro-4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carb oxamide

: 1221442-95-0
N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 40h; Inert atmosphere;

Reference yield:

: 1221443-39-5
5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane

: 1221442-95-0
N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / ethanol / 3 h

2: triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl acetamide / 40 h / 20 °C / Inert atmosphere

With hydrogen; caesium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 32933-03-2
ethyl 1-acetylcyclopropanecarboxylate

: 1221442-95-0
N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / toluene-4-sulfonic acid / 8 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 0 - 50 °C / Inert atmosphere

4: hydrogen / palladium on activated charcoal / ethanol / 3 h

5: triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 0 °C / Inert atmosphere

7: caesium carbonate / N,N-dimethyl acetamide / 40 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; lithium aluminium tetrahydride; hydrogen; caesium carbonate; triethylamine; palladium on activated charcoal; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;