2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide
CAS No.:1013696-04-2
Molecular Formula:C₂₁H₁₂Cl₂F₃N₃O₃S
Molecular Weight:514.312
Hs Code.:

Synonyms:2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

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Chemical Property of 2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

Chemical Property:

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Technology Process of 2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

There total 3 articles about 2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175205-54-6
2-chloro-4-(trifluoromethyl)benzenesulfonyl chloride

: 1013695-64-1
5-chloro-6-(quinolin-3-yloxy)pyridin-3-amine

: 1013696-04-2
2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2012.10.027

Reference yield:

: 22353-38-4
3-chloro-2-hydroxy-5-nitropyridine

: 1013696-04-2
2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: quinoline; trichlorophosphate / 2 h / 0 - 120 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3: tin(II) chloride dihdyrate / ethyl acetate / 8 h / 20 °C

4: pyridine / dichloromethane / 20 °C

With pyridine; quinoline; tin(II) chloride dihdyrate; caesium carbonate; trichlorophosphate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.10.027

Reference yield:

: 22353-40-8
2,3-dichloro-5-nitropyridine

: 1013696-04-2
2-chloro-N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)-4-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2: tin(II) chloride dihdyrate / ethyl acetate / 8 h / 20 °C

3: pyridine / dichloromethane / 20 °C

With pyridine; tin(II) chloride dihdyrate; caesium carbonate; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.10.027